


Locally owned in Raleigh, MS, serving Smith County families with free delivery, curbside pickup, and pharmacist care you can count on.

From refills and vaccines to Medicare Part D help, med sync, and durable medical equipment, our pharmacists support every part of your family's medication routine right here in Raleigh.




Little's Pharmacy has served Raleigh and Smith County since 1947, continuing the Little family legacy under owner-pharmacist Josh Pierce and his partner, Kristi Welch.
Our goal is simple, meet the needs of our community with friendly, personal service. We combine retail, immunizations, and medical equipment under one trusted Main Street roof.
I just moved to Raleigh and I'd always used Walmart pharmacy. I couldn't get Walmart to answer their phone. I called Little's and they got my prescriptions transferred here. What a great choice. Little's rocks ❤️❤️
Request a refill online in seconds, then choose free local delivery, curbside pickup, or in-store pickup at our Main Street pharmacy in Raleigh.
122 Main Street, Raleigh, Mississippi, 39153

Refill prescriptions by scanning the bottle, plan your daily doses, and stay on track with reminders, all from the free Rx Local mobile app.



We are a proud Good Neighbor Pharmacy member, giving our independent store the buying power, technology, and adherence tools of a national network with hometown service.
Answers to the questions we hear most often from new RX Local users at Little's Pharmacy.
Yes, the app is completely free. Download it from the App Store or Google Play and create your account at no cost.
Bring your refills to Raleigh's locally owned pharmacy and feel the difference of friendly service, free delivery, and pharmacists who know your name.

Our goal is simple, treat every patient like family and meet the real needs of our Smith County community every single day.